The rosuvastatin (Crestor®) manufacturer’s information does not mention a grapefruit juice interaction. Grapefruit juice has much less of an effect on pitavastatin (Livalo ®) and pravastatin ( Pravachol ®). Grapefruit juice also affects lovastatin (Mevacor ®).The combination can increase the risk of muscle pain and breakdown of muscle tissue. Simvastatin ( Zocor ®): The manufacturer’s information for simvastatin states that you should avoid large quantities (>1 quart daily) of grapefruit juice in combination with simvastatin.The combination of atorvastatin and grapefruit juice can increase the risk of muscle pain, tenderness, and weakness or can even cause liver and kidney problems. Atorvastatin levels can also increase (but not as much) when you drink as little as an 8-ounce cup of grapefruit juice daily. Atorvastatin ( Lipitor ®): Levels of atorvastatin can increase when you drink an excessive amount (≥ 750 ml to 1.2 liters) of grapefruit juice per day.Since the topic of grapefruit juice and statins seem to come up quite a bit, let’s dive a little deeper into this interaction by looking at some of the most common statins involved in grapefruit juice interactions. Consult your healthcare provider to determine if grapefruit juice is safe with all medicines (prescription and OTC) you take. Never stop taking any of your medications without speaking with your healthcare provider first, as it may cause serious harm. Other drug interactions with grapefruit juice (or other juices) may occur. Estrogen, oral contraceptives ( birth control pills).Allegra® (fexofenadine): over-the-counter (OTC) allergy medicine.Pacerone ® (amiodarone): used to treat abnormal heart rhythm.Entocort ® EC and Uceris ® (both contain budesonide).Statins (used to treat high cholesterol):Ĭalcium channel blockers (used to treat high blood pressure) The following drugs can interact with grapefruit juice: Keep in mind that the extent of the interaction varies by person, medicine, and the amount of grapefruit juice you drink. What Medications Interact with Grapefruit Juice? If too much atorvastatin or another statin builds up in your body, you can suffer from liver and muscle damage and even kidney failure.īecause everyone has a different amount of CYP3A4 in their intestines, grapefruit juice may affect people differently. When the enzyme can’t process the medication as efficiently, the drug levels can build up, causing worsened or more severe side effects. Many drugs are processed by an enzyme called cytochrome P450 3A4 (CYP3A4). How Does Grapefruit Juice Interact with Medications? Continue reading to learn all about grapefruit juice and drugs. Grapefruit juice interacts with certain medications, which can lead to unwanted consequences. The reason to avoid grapefruit is not that it is unhealthy. You may be thinking, what? Grapefruit juice? How does that affect my cholesterol? Isn’t grapefruit a healthy citrus fruit – full of vitamin C – that should be part of a balanced diet? Did he or she tell you also to avoid grapefruit and grapefruit juice? If you take cholesterol medication, like atorvastatin (Lipitor ®), your doctor probably told you to avoid fried foods, fatty foods, and sugar. EverlyWell Review: What You Need To Know Before You Order a Test.Seed Probiotics Review: What Makes These Supplements Unique?.The Pill Club Reviews: Are Their Birth Control Products Legit?.Keeps Review: Does This Hair Loss Treatment Actually Work?.
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